Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides.
نویسندگان
چکیده
Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 97 شماره
صفحات -
تاریخ انتشار 2016